Objectives Fluoride levels in the public water supplies of 40 Brazilian cities were analyzed and classified on the basis of risk/benefit balance.Material and Methods Samples were collected monthly over a seven-year period from three sites for each water supply source.The samples were analyzed in duplicate in the laboratory of the Center for Researc
BK virus (BKV) associated nephropathy affects 1-10% of kidney transplant recipients, leading to graft failure in about 50% of cases.Immune responses against different BKV antigens have been shown to have a prognostic value for disease development.Data currently suggest that the structural antigens and regulatory antigens of BKV might each trigger a
Genome editing is a set of techniques for introducing targeted changes in genomes.It may be achieved by enzymes collectively called site-directed nucleases (SDN).Site-specificity of SDNs is provided either by the DNA binding domain of the protein molecule itself or by RNA molecule(s) that direct SDN to a specific site in the genome.In contrast to t